Publications

  • Manieri E, Tie G, Seruggia D, Madha S, Maglieri AH, Huang K, Fujiwara Y, Zhang K, Orkin SH, McCarthy N, Shivdasani RA. Structure, signals, and cellular elements of the mouse gastric mesenchymal niche. Biorxiv 2023 doi.org/10.1101/2023.02.11.527728
  • Mehta S, Buyanbat A, Kai Y, Karayel O, Goldman S, Seruggia D, Zhang K, Fujiwara Y, Donovan K, Zhu Q, Yang H, Nabet B, Gray N, Mann M, Fischer E, Adelman K, Orkin SH. Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells. Cell Chemical Biology 2022 doi.org/10.1016/j.chembiol.2022.06.007.
  • Singh H, Seruggia D, Madha S, Saxena M, Nagaraja AK, Wu Z, Zhou J, Huebner AJ, Maglieri A, Wezenbeek J, Hochedlinger K, Orkin SH, Bass AJ, Hornick JL, Shivdasani RA. Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer. Genes and Development 2022 doi/10.1101/gad.348983.121.
  • Shahin T, Kuehn HS, Shoeb MR, Gawriyski L, Giuliani S, Repiscak P, Hoeger B, Petronczki OY, Bal SK, Zoghi S, Dmytrus J, Seruggia D, Castanon I, Rezaei N, Varjosalo M, Halbritter F, Rosenzweig S, Boztug K. Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity. Science Immunology 2021 doi: 10.1126/sciimmunol.abe3981
  • Seruggia D, Fernández A, Cantero M, Fernandez-Miñan A, Gomez-Skarmeta JL, Pelczar P, Montoliu L. Boundary sequences flanking the mouse tyrosinase locus ensure faithful pattern of gene expression. Scientific Reports 2020 doi.org/10.1038/s41598-020-72543-0
  • Cai W, Huang J, Zhu Q, Li BE, Seruggia D, Zhou P, Nguyen M, Fujiwara Y, Xie H, Yang Z, Hong D, Ren P, Xu J, Pu WT, Yuan GC, Orkin SH. Enhancer-dependence of gene expression increases with developmental age. PNAS 2020 doi: 10.1073/pnas.2008672117
  • Manieri E, Estaban-Lafuente L, Rodriguez ME, Leiva-Vega L, Cubero FJ, Barrett T, Cavanagh-Kyros J, Seruggia D, Monte MJ, Marin J, Davis RJ, Mora A, Sabio G. JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma. PNAS 2020 Jun 29;202002672 doi.org/10.1073/pnas.2002672117
  • Seruggia D, Oti M, Tripathi P, Canver MC, LeBlanc L, Di Giammartino DC, Bullen MJ, Nefzger CM, Sun YBY, Farouni R, Polo JM, Pinello L, Apostolou E, Kim J, Orkin SH, Das PP. TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Mol Cell. 2019 doi: 10.1016/j.molcel.2019.03.025
  • Sher F1, Hossain M1, Seruggia D1, Schoonenberg VAC, Yao Q, Cifani P, Dassama LMK, Cole MA, Ren C, Vinjamur DS, Macias-Trevino C, Luk K, McGuckin C, Schupp PG, Canver MC, Kurita R, Nakamura Y, Fujiwara Y, Wolfe SA, Pinello L, Maeda T, Kentsis A, Orkin SH, Bauer DE. Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis. Nat Genet. 2019 (1equal contribution) doi: 10.1038/s41588-019-0453-4
  • Debruyne DN, Dries R, Sengupta S, Seruggia D, Day D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Marco E, Chen T, Gray NS, Wong K, Orkin SH, Yuan GC, Young RA, George RE. BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Nature 2019 doi: 10.1038/s41586-019-1472-0
  • Di Pilato M, Kim EY, Cadilha BL, Prüßmann JN, Nasrallah MN, Seruggia D, Usmani SM, Misale S, Zappulli V, Carrizosa E, Mani V, Ligorio M, Warner RD, Medoff BD, Marangoni F, Villani AC, Mempel TR. Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy.  Nature. 2019 doi: 10.1038/s41586-019-1215-2
  • LeBlanc L, Lee BK, Yu AC, Kim M, Kambhampati AV, Dupont SM, Seruggia D, Ryu BU, Orkin SH, Kim J. Yap1 safeguards mouse embryonic; stem cells from excessive apoptosis during differentiation. Elife 2018 doi: 10.7554/eLife.40167
  • Seruggia D, Fernández A, Cantero M, Pelczar P, Montoliu L. Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR-Cas9-mediated mutagenesis. Nucleic Acids Res. 2015 doi: 10.1093/nar/gkv375
  • Wang J, Vicente-García C, Seruggia D, Moltó E, Fernandez-Miñán A, Neto A, Lee E, Gómez-Skarmeta JL, Montoliu L, Lunyak VV, Jordan IK. MIR retrotransposon sequences provide insulators to the human genome. PNAS. 2015 doi: 10.1073/pnas.1507253112
  • Hermann M, Stillhard P, Wildner H, Seruggia D, Kapp V, Sánchez-Iranzo H, Mercader N, Montoliu L, Zeilhofer HU, Pelczar P. Binary recombinase systems for high-resolution conditional mutagenesis. Nucleic Acids Res. 2014 doi: 10.1093/nar/gkt1361

full list here